The Antigenicity of the Tumor Cell — Context Matters

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The Antigenicity of the Tumor Cell — Context Matters

When is a neoantigen not a neoantigen? A recent study suggests that T cells in a patient with cancer are more likely to “miss” mutant peptides generated by somatic mutations than are the T cells in a healthy person.

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SOURCE INFORMATION

From the Department of Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital, Lørenskog, and the Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo — both in Norway.

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